A state of physical or mental suffering
To bring great harm or suffering to
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A look of anguish crossed Jonny's face.
Terrible anguish struck her heart, she felt a dreadful ache as if something was being torn inside her and she were dying.
I try not to anguish over the little things.
He gazed up at her, smiled through the anguish his eyes betrayed and stood.
The physical pain penetrated his mental anguish, and he lowered his weapons.