noun
Substance
body, material, substantiality, corporeality, corporeity, protoplasm, constituents, stuff, materialness, object, thing, physical world; see also element 2.
Antonyms nothing*, nihility, immateriality.
Difficulty
trouble, distress, perplexity; see difficulty 2.
Subject
interest, focus, resolution; see subject 1, theme 1, topic.
An affair
undertaking, circumstance, concern; see affair 1.
Pus
suppuration, maturation, discharge, purulence, ulceration, infection; see also sore.
as a matter of fact
for that matter
in regard to that, as far as that is concerned, concerning that; see and.
no matter
it doesn't matter, it is of no concern, regardless of; see regardless 2.