Literally confined in bonds
fettered, shackled, trussed up, manacled, chained, enchained, handcuffed, hobbled, captive, confined, restrained, trammeled, pinioned, pilloried, muzzled, in leash, tied up, harnessed, bound hand and foot, lashed fast, swathed, pinned down, pegged down, tethered, picketed, secured, roped, gagged, hogtied, loaded with irons*.
Antonyms free*, unrestrained, loose.
Figuratively constrained
impelled, compelled, obliged, obligated, under compulsion, constrained, duty-bound, committed, sworn, pledged, forced, coerced, driven, necessitated, under necessity, made, having no alternative, required, bounden.
Antonyms unconstrained, free*, independent.