To perform a function effectively
To control or direct the functioning of
To control the course of (an activity)
To react in a specified way
To keep in operation
To be in operation
To produce an effect
To carry out a surgical procedure
I hope you will find him sympathetic and ready to co- operate in promoting all that is reasonable.
It did not operate as a rule beyond the limits of race.
In England, in addition to the Marconi Company, the Lodge-Muirhead Syndicate was formed to operate the inventions of Sir Oliver Lodge and Dr Muirhead.
That's up to you but you'll need me to operate the machines.
A third Italian army would, if expedient, pass into Germany, to operate against either France or Russia.