To use with or as if with the hands
To handle in a way so as to mix, form, and shape
To control to one's own advantage by artful or indirect means
He's the only one who knew how to manipulate them.
My gift is the ability to manipulate minds.
Robots can manipulate matter smaller than we can even see, and robots can effortlessly manipulate objects that weigh many tons.
He wasn't interested in marriage and he didn't want her trying to manipulate him into it.
Men are easy to manipulate, as you well know.