Another word for far-reaching

Many practitioners believe that a far-reaching number of illnesses are cause by the stress in our lives.

I guess people don't realize the far-reaching aspects of cheating.

In person Madame Roland was attractive though not beautiful; her ideas were clear and far-reaching, her manner calm, and her power of observation extremely acute.

Sooner probably than anybody else he realized the far-reaching implications of the theory propounded by Planck.

The results produced by the king's execution were far-reaching and permanent.