Synonyms for grief

noun

1. Mental distress

   sorrow, sadness, regret, melancholy, vexation, mourning, misery, trouble, anguish, bereavement, painful regret, distress over loss, depression, despondency, pain, worry, harassment, anxiety, woe, heartache, repining, lamentation, dole, dolor, malaise, disquiet, discomfort, smart, mortification, affliction, gloom, unhappiness, wretchedness, infelicity, desolation, despair, agony, torture, purgatory.

   Antonyms happiness*, exhilaration, pleasure.

2. The cause of distress

   affliction, tribulation, vexation; see difficulty 2.

come to grief