Heavy spirits
woe, sadness, depression, dejection, melancholy, melancholia, dullness, despondency, misery, sorrow, morbidity, pensiveness, hypochondriasis, catatonia, dolor, malaise, vexation, pessimism, foreboding, low spirits, cheerlessness, heaviness of mind, weariness, apprehension, misgiving, distress, affliction, despair, oppression, anguish, grief, horror, mourning, bitterness, mortification, chagrin, discouragement, disconsolateness, the blues*, the dumps*, the doldrums*, blue funk*.
Antonyms happiness*, optimism, gaiety.