noun
misery, poverty, despondency, unhappiness, distress, grief, trouble, affliction, abjection, woe, sadness, disillusionment, depression, melancholia, dejection, discomfort, discontent, tribulation, torment, desperation, despair, desolation, bitterness, blue funk*, dumps*, blues*, doldrums*.
Antonyms happiness*, joyousness, exuberance.