The revision of the constitution had estranged the two heads of the Liberal party, I.
During that period he became even more estranged from the majority of the republicans.
One couple is sleeping apart, so I suppose Ginger and Joseph are already estranged.
Unable to take any serious part in affairs of state, Darnley soon became estranged from his wife.
For the remainder of his life George was rather estranged from his former allies the Hungarians.