To harm irreparably through inept handling; make a mess
Basically, it started with a screw up.
I'm a screw-up, but she isn't.
Did I screw up somewhere along the line?
They started hauling out the booze and I don't want to do anything to screw up a scholarship—especially now.
All that needed to be done was to fish the fractured ribs of the high arches, put oval holes in the fishes, and not screw up the bolts too tight.