A pain in the head
migraine, sick headache, bilious headache, neuralgia, organic headache, megrim, cephalalgia, hemialgia, hemicrania, reflex headache, head-on*, big head*; see also pain 2.
*A source of vexation and difficulty
problem, jumble, mess; see difficulty 1, 2, trouble 2.
A duty or responsibility that is a source of anxiety, worry, or hardship:
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