Pale and exhausted, as because of worry or sleeplessness
That feeling was so strong at the moment of leaving Voronezh that those who saw her off, as they looked at her careworn, despairing face, felt sure she would fall ill on the journey.
careworn face recalls it by association.
careworn look, the weary eye, the heavy step.
My younger sister and I carried out several operations on him so he looked rather careworn.