In 456 it was seized by Genseric. It was retaken Byzantine period.
The Byzantine army captured fifteen thousand prisoners.
in 987; between 1018 and 1186, under Byzantine rule, it served as a frontier fortress.
Philomelion was probably a Pergamenian foundation on the great Graeco-Roman highway from Ephesus to the east, and to its townsmen the Smyrniotes wrote the letter that describes the martyrdom of Polycarp. Cicero, on his way to Cilicia, dated some of his extant correspondence there; and the place played a considerable part in the frontier wars between the Byzantine emperors and the sultanate of Rum.
It is certainly derived, through Rossiya, from Slavonic Rus or Ros (Byzantine `Pws or `Pc o-oc), a name first given to the Scandinavians who founded a principality on the Dnieper in the 9th century; and afterwards extended to the collection of Russian states of which this principality formed the nucleus.