Referring to physical anguish
sore, raw, aching, throbbing, burning, torturing, hurtful, biting, piercing, sharp, severe, caustic, tormenting, smarting, extreme, grievous, griping, stinging, lacerating, bruised, sensitive, tender, irritated, irritable, vexatious, distressing, agonizing, excruciating, torturous, grievous, inflamed, burned, unpleasant, ulcerated, abscessed, uncomfortable; see also sore.
Antonyms healthy*, comfortable, well.