See downfall in Webster's New World Roget's A-Z Thesaurus II
noun
A sudden drop to a lower condition or status:
comedown, descent, down, downgrade. See riseA disastrous overwhelming defeat or ruin:
collapse, fall, waterloo. See thriveSomething that causes total loss or severe impairment, as of one's health, fortune, honor, or hopes:
bane, destroyer, destruction, ruin, ruination, undoing, wrecker. See help
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