An inclination to something
He showed a predilection for poetry.
He displayed an early predilection for zoology and ornithology, and in later life became a skilled and enthusiastic collector, particularly of African plants and birds.
The student had a predilection for some subjects and against others.
The junkie had a predilection for the more illicit things in life.
In addition, primary skin tumors such as melanoma have a predilection to spread to the liver.