From all these it finally disappeared about 1680, at the close of a period of pandemic prevalence.
In short, if we regard the history of this disease as a whole, it appears to have lost such power from the time of the Great Plague of London in 1665, which was part of a pandemic wave, until the present day.
And even in the East plague was confined to more or less clearly localized epidemics; it showed no power of pandemic diffusion.
Diffusion.-At the outset it is characteristic of this subtle disorder that the present pandemic diffusion cannot be traced with certainty to a definite time or place of origin.
In the 1918-19 Spanish flu pandemic, the death toll reached a staggering 20 to 40 million worldwide.