The common variety of bed-sore is the result of continuous pressure on and irritation of the skin, the vitality and resisting power of which are lowered by a lesion of the cord cutting off the trophic supply to the skin affected.
In another class of diseases, the organisms. first produce some well-marked local lesion, from which secondary extension takes place by the lymph or blood stream to other parts of the body, where corresponding lesions are formed.
The acute bed-sore is, in some cases, a true trophic lesion occurring, as it may, on parts not subjected to continuous pressure or irritation.
Syphilitic lesion of the arteries, and likewise of other fibrous tissues, often involves grave consequential damage to nervous structures fed or supported by such parts.
A post mortem examination was held, which showed not only grave derangement in the stomach and other organs, but a serious lesion of the brain.