Calcium supplementation was associated with a modest but not significant reduction in the risk of adenoma recurrence.
In the mouse study, there was a significant increase in the incidence of hepatocellular adenoma or carcinoma.
In cases of aldosterone-producing adenoma, surgery in the second trimester is the most appropriate option to avoid a poor obstetric outcome.
Conn's syndrome is also very rare, caused by a benign adenoma or hyperplasia of the zona glomerulosa producing excess aldosterone.
These include intussusception, when the adenoma may act as a lead point and cause the duodenum to telescope on itself.