Hoffmann (52) from essential syphilitic lesions, and now known as Treponeina (Spirochaete) pallida, Schaud.
An illness with no serious effects on humans, cowpox caused lesions on cows' udders which then could spread to dairymaids' hands.
In man, actually gross sensory defects follow even limited lesions of the cortex.
The hallmark lesions of these diseases are vacuoles and plaques, which are small round formations consisting of deposits of a protein called amyloid.
Stroke lesions to the left hemisphere can cause aphasia for sign that is analogous to the aphasias of speech.
