Activity dependent excitability changes of nociceptors and mechanoreceptors Sensory neurons of the dorsal root ganglion are functionally heterogeneous.
Substance P Nerves from nociceptors use this peptide to activate relay neurons in the spinal cord.
As a group, these pain-sensing neurons are called nociceptors, and virtually every surface and organ of the body is wired with them.
Nociceptors are classified according to the stimulus that prompts them to transmit a pain signal.
Thermoreceptive nociceptors are stimulated by temperatures that are potentially tissue damaging.