For the chronic form of industrial poisoning in the manufacture of lucifer matches - a form of necrosis, known in England as " phossy jaw " and in France as " mal chimique," a localized inflammatory infection of the periosteum, ending with the death and exfoliation of part of the bone - see Match.
The usual necrosis of the injured cortex occursdrying up, shrivelling, and consequent stretching and cracking of the dead cortex on the wood beneath.
Such frost-cracks, sun-cracks, &c., may then be slowly healed over by callus, but if the conditions for necrosis recur the crack may be again opened, or if Fungi, &c., interfere with occlusion, the healing is prevented; in such cases the local necrosis may give rise to cankers.
The disease organisms then cause the death (necrosis) of bowel tissue or gangrene of the bowel.
Tumor necrosis factor alpha also plays a pivotal part in inflammation.