Its use in febrile diseases, at one time extensive, is now obsolete.
The labours of Golgi, Marchiafava, Celli and others established the nature of the parasite and its behaviour in the blood; they proved the fact, guessed by Rasori so far back as 1846, that the periodical febrile paroxysm corresponds with the development of the organisms; and they showed that the different forms of malarial fever have their distinct parasites, and consequently fall into distinct groups,.
Salicylates are the next safest to quinine of all antipyretics, whilst being much more powerful in all febrile states except malaria.
According to Sir Thomas Fraser nothing else can compete with alcohol as a food in desperate febrile cases, and to this use must be added its antipyretic power already explained and its action as a soporific. During its administration in febrile cases the drug must be most carefully watched, as its action may prove deleterious to the nervous system and the circulation in certain classes of patient.
His chief works were First Lines of the Practice of Physic (1774); Institutions of Medicine (1770); and Synopsis Nosologicae Medicae (1785), which contained his classification of diseases into four great classes - (t) Pyrexiae, or febrile diseases, as typhus fever; (2) Neuroses, or nervous diseases, as epilepsy; (3) Cachexiae, or diseases resulting from bad habit of body, as scurvy; L and (4) Locales, or local diseases, as cancer.