The most effective step would obviously be the extermination of the Anopheles mosquito.
In the century leading up to its extermination, smallpox killed about 500,000,000 people.
Hunting, extermination, as methodical and merciless as he knew himself capable of.
Formerly giraffes were found in large herds, but persecution has reduced their number and led to their extermination from many districts.
Measures for the extermination of the malarial mosquito are carried on with good effect.