In the century leading up to its extermination, smallpox killed about 500,000,000 people.
The most effective step would obviously be the extermination of the Anopheles mosquito.
Measures for the extermination of the malarial mosquito are carried on with good effect.
Palpalis, although in South Africa there can be no question that the extermination of big game has been followed or accompanied by the disappearance of tsetse from many localities in which they formerly abounded.
It has shared the vicissitudes of the nation itself and like it been in danger of extermination at the hands of fanatic foes.