In October 1587 both the grand duke and his wife died of colic within a couple of days of each other.
His bouts of pleasure gradually weakened his constitution; a severe colic, which seized him on the march of the army against Hamadan, was checked by remedies so violent that Avicenna could scarcely stand.
To avoid colic an animal has to be gradually prepared by giving small quantities of green food for a few days before going to grass.
To the left of the colic impression is a smaller one for the second part of the duodenum.
" Biliary colic " is the name given to the distressing symptoms associated with the passage of a stone through the narrow bileduct.