Discovery in these various directions then led physicians to regard fever and inflammation not as separable entities, but as fluctuating symptomgroups, due to swervings of function from the normal balance under contingent forces.
Various morbid conditions of the body generally may give rise to different symptoms. Thus a gouty condition may manifest itself in one man as eczema of the skin, giving rise to redness and intense itching; in another as neuralgia, causing most severe pain; in a third as bronchitis, producing a distressing cough; in a fourth as dyspepsia, giving rise to flatulence and intestinal disturbance; and in a fifth as inflammation of the great toe, accompanied by redness, swelling and pain.
Meanwhile Cohnheim and Metchnikoff were engaged in destroying the ontological conception not of fever only, but also of inflammation, of which, as a local event, an ontological conception was no less strongly implanted.
The great danger is that, as the blood in the vessels becomes thawed, there will be so much reactionary flow through the tissues that acute inflammation will follow.
He shows no inconsiderable knowledge of anatomy in his remarkable description of inflammation and abscess of the mediastinum in his own person, and its diagnosis from common pleuritis as well as from abscess and dropsy of the pericardium.