Symptoms that may indicate the diagnosis include unexplained severe pain that increases rapidly over time associated with systemic toxicity including hypotension.
The effectiveness of most vasodilators is, however, reduced in the hypertensive lung and they cause systemic hypotension.
Cancer vaccines are currently being developed to confer active, specific immunotherapy directed against tumor-associated antigens, while inducing minimal systemic toxicity.
It is a progressive, systemic autoimmune disease characterized by inflammation of the membrane lining in joints.
Dexamethasone is the preferred agent for systemic administration and triamcinolone for epidural injection.