It was not possible to define a clear response curve of PD excretion to purine absorption from that data set.
Man and other primates excrete uric acid as the final product of purine catabolism as the result of lacking uricase.
Methotrexate which interferes with purine metabolism was introduced almost 50 years ago.
The phosphorylation of purine nucleosides to form nucleotides by nucleoside kinase is an alternative pathway of purine salvage.
The usual choice for reducing uric acid levels is allopurinol, because it inhibits xanthine oxidase and can depress new purine synthesis.