Needless to say it opened up Pandora's box.
Kratos must find Pandora's box and use it to kill Ares, but he also lets out a thousand years worth of Olympian secrets.
Now, it wants open the Pandora's Box of genetically-engineered smallpox.
Well, shame on you for opening Pandora's Box with your infernal questioning!
They fear that he is going mad, and so they have commanded Kratos to find Pandora's Box and use it to kill his master.