More remarkable still, animals inoculated with such " attenuated " bacilli proved to be curiously resistant to the deadly effects of subsequent inoculations of the non-attenuated form.
Here manifestly the dose may be easily controlled, and may be gradually increased in successive inoculations.
In the development of toxin-immunity the doses, small at first, are gradually increased in successive inoculations; or, as in the case of very active toxins, the initial injections are made with toxin modified by heat or by the addition of various chemical substances.
Last night's meeting heard that tannery workers in the 1960's were given annual inoculations against anthrax.
All this results in differing degrees of receptivity in experimental inoculations.