He died from the bite of a serpent which sprang from the blood of the Gorgon Medusa.
Here Perseus, returning from having slain the Gorgon, found her, slew the monster, set her free, and married her in spite of Phineus, to whom she had before been promised.
The Attic tradition, reproduced in Euripides (Ion 1002), regarded the Gorgon as a monster, produced by Gaea to aid her sons the giants against the gods and slain by Athena (the passage is a locus classicus on the aegis of Athena).
As Such she appears in Homer and Hesiod and in post-Homeric legend as the slayer of the Gorgon and taking part in the battle of the giants.
The story of the slaying of Medusa by Athena, in which there is no certain evidence that she played a direct part, explained by Roscher as the scattering of the storm-cloud, probably arose from the fact that she is represented as wearing the Gorgon's head as a badge.