Subsequently, however, researchers concluded that the rare recurrence of OI to a couple with a child with autosomal dominant OI is more likely due to gonadal mosaicism.
An estimated 2 percent to 4 percent of families into which an infant with OI type II is born are at risk of having another affected child because of gonadal mosaicism.
The pituitary hormones are the same for males and females, but the gonadal hormones are different.
Normal gonadal function is required for normal male development of the genital tract and for maintenance of some elements of male sexual behavior.
Replacement with testosterone prevents these changes, suggesting that an intact male gonadal system is required to maintain sexual function.