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Amino acid chelates are extremely stable over the whole pH range found in the gastrointestinal tract.
A benchtop model was constructed reproducing the nitrite chemistry occurring within the lumen of the upper gastrointestinal tract where saliva encounters acidic gastric juice.
Some enzymatic hydrolysis of the drug may occur in the gastrointestinal tract prior to its absorption.
The gases normally present in the gastrointestinal tract are oxygen, carbon dioxide, nitrogen, hydrogen, methane, and hydrogen sulfide.
It is only poorly absorbed from the gastrointestinal tract in the presence of intact mucosa.