Other effects related to acid inhibition During treatment with antisecretory drugs, serum gastrin increases in response to the decreased acid secretion.
Excessive secretion of gastrin (a hormone secreted into the stomach to aid in digestion) by these tumors can cause upper gastrointestinal ulcers.
They do however produce other gastrointestinal hormones including gastrin and VIP.
The stomach wall also secretes gastrin while the kidney produces the hormone renin.
This gives a sensitivity of 85% when performed on all patients with a fasting gastrin of less than 400 pmol/l.