These include generally loose joints, low muscle tone at birth, scoliosis at birth (which worsens with age), and a fragility of the eyes, which may give the white area of the eye a blue tint or cause the eye to rupture.
Other factors must be considered when designing the ring, such as the fragility of each particular jewel and if the setting needs to protect the piece from chips and wear and tear.
These include thin translucent skin, arterial/intestinal/uterine fragility or rupture, extensive bruising, and characteristic facial appearance.
In a condition known as purpura simplex, there is a tendency to bruise easily due to an increased fragility of the blood vessels.
Comprising of several shows from the Fragility tour, NIN released a live DVD/CD entitled And All That Could Have Been (the title being a lyric from "The Great Below" from The Fragile).