The SmPC describes in some detail the hearing impairment in patients receiving cisplatin and notes that it is worse in children.
Studies were excluded if they used cisplatin and carboplatin in the same arm or used drugs not considered established cytotoxics.
Drugs that are often investigated in combination with radiotherapy include cisplatin, capecitabine and 5FU.
Combinations containing cisplatin, cyclophosphamide and doxorubicin were studied in the 1980s and showed improved median progression-free survival.
Treatment In the 1970s, a breakthrough drug called cisplatin was developed that dramatically improved the outlook for men with advanced testicular cancer.