Synonyms for tire

noun

wheel, casing, tire and tube; see wheel 1.

Varieties of tires include: tubeless, radial, steel-belted radial, snow, mud, all-terrain, studded, whitewall, puncture-proof, recapped, low-pressure, synthetic, natural rubber, solid rubber, pneumatic, oversize, airplane, automobile, motorcycle, bicycle, recap*, retread*, spare*, baloney*, doughnut*, rubber toe*, sneaker*, shoe*.

verb

To become exhausted
grow weary, to become fagged, break down, droop, flag, jade, pall, faint, drop, puff, sink, yawn, collapse, give out, prostrate, wilt*, go stale*, poop out*, burn out*, burn the candle at both ends*; see also weary 2.
Antonyms rest*, awake, relax.
To make a person exhausted
tax, overtax, harass, fatigue, exhaust, overwork, strain, overstrain, overburden, depress, dispirit, pain, vex, worry, distress, deject, dishearten, unman, prostrate, wear out, run a person ragged*, do up*, do in*, take the tuck out of*; see also weary 1.
To bore
annoy, exasperate, displease; see bother 2, weary 1.

See tire in American Heritage Dictionary 4 Synonyms

tire ¹weary fatigue exhaust jade ²

These verbs mean to cause or undergo depletion of strength, energy, spirit, interest, or patience. Tire often suggests a state resulting from exertion, excess, dullness, or ennui: “When a man is tired of London, he is tired of life” (Samuel Johnson).
Weary often implies dissatisfaction, as that resulting from what is irksome or boring: found the long journey wearying; soon wearied of their constant bickering.
Fatigue implies great weariness, as that caused by stress or overwork: “fatigued by an endless rotation of thought and wild alarms” (Mary Wollstonecraft).
To exhaust means to wear out completely, and it connotes total draining of physical or emotional strength: “Like all people who try to exhaust a subject, he exhausted his listeners” (Oscar Wilde).
Jade refers principally to dullness that most often results from overindulgence: “Contemplation of works of art without understanding them jades the faculties and enslaves the intelligence” (John Ruskin).

See tire in Webster's New World Roget's A-Z Thesaurus II

verb

To diminish the strength and energy of:
drain, fatigue, jade, wear, wear down, wear out, weary. See tired
To fatigue with dullness or tedium:
bore, weary. See excite