The nature of sterilization, and the difficulties in securing it, as well as the extreme delicacy of the manipulations necessary, made it possible for a very long time to be doubtful as to the application of the phrase omne vivum e vivo to the microscopic world, and there still remain a few belated supporters of abiogenesis.
In vivo, it has been shown to display good potency when compared to existing therapies and has good oral bioavailability.
A large unknown area in pectin chemistry concerns the possible presence in vivo of covalent cross-links between pectic molecules.
From the 17th century onwards it was gradually shown that, at least in the case of all the higher and readily visible organisms, abiogenesis did not occur, but that omne vivum e vivo, every living thing came from a pre-existing living thing.
By doing this they are protecting natural populations in the forest, sustaining biological diversity in vivo.