Explain how blood clots by platelets producing thrombin, which converts soluble fibrinogen into insoluble fibrin.
Thrombin is formed from prothrombin by a prothrombin activator, itself the end of a series of reactions.
The anti-coagulant heparin activates the inhibitor antithrombin III, which deactivates several of the plasma clotting factors, including thrombin III, which deactivates several of the plasma clotting factors, including thrombin.
The anti-coagulant heparin activates the inhibitor antithrombin III, which deactivates several of the plasma clotting factors, including thrombin.
An example of the use of simple molecules for directed screening for thrombin inhibitors will be presented.