In the mouse study, there was a significant increase in the incidence of hepatocellular adenoma or carcinoma.
In these situations the hepatocellular function is normal but overwhelmed and so the increased bilirubin is for the most part unconjugated.
Hepatocellular function is normal (although it may deteriorate in prolonged obstruction) so the excess plasma bilirubin is chiefly conjugated.
There was a single hepatocellular carcinoma in the female high dose group.
Elevated bilirubin, alanine transaminase and lactate dehydrogenase concentrations are indicative of hepatocellular injury.