Fibrinogen occurs in the blood plasma, and is changed by a ferment into fibrin, to which the clotting of blood is due.
Lying between the fibrin mass and the healthy tissues is a zone of injured and degenerated tissue elements, the result of the trauma.
Next, blood coagulation rapidly replaces this unstable platelet plug with a stable fibrin clot.
Haemostatic mechanisms control blood flow by regulating platelet adherence and fibrin deposition and various haemostatic proteins have been shown to regulate angiogenesis.
Blood clots (thrombi) are clumps of a naturally-occurring protein called fibrin which can accumulate in a blood vessel.