However, no excess chromosomal aberrations in circulating human lymphocytes have been observed in patients treated for 8 months.
Overall, the COM concluded that the results from the in vitro chromosomal aberration assays were likely to represent a cytotoxic response.
In addition, chromosomal deletions of up to 2kb were detected at all 14 integrations sites examined.
Comparative genomic hybridization findings showed chromosomal imbalances in 9 of 12 cases of choriocarcinoma.
Chromosomal instability is thought to occur in 85 per cent of all colorectal cancer cases.