Calcium citrate must be manufactured with care to avoid an excess of chalk or lime, which would precipitate constituents of the juice that cause the fermentation of the citrate and the production of calcium acetate and butyrate.
Referring to the esters C9H1802 previously mentioned, it is seen that the highest boilingpoints belong to methyl octoate and octyl formate, the least symmetrical, while the minimum belongs to amyl butyrate, the most symmetrical.
Butyrate, a substance widely used as a food additive, was also being investigated as of 2004 as an agent that may increase fetal hemoglobin production.