The queen of Castile whose marriage to Ferdinand of Aragon in 1469 marked the beginning of the modern state of Spain; they instituted the Spanish Inquisition in 1478 and sponsored the voyages of Christopher Columbus in 1492 (1451-1504)
He represented to Ferdinand and Isabella that it was essential to their safety to reorganize the Inquisition, which had since the 13th century (1236) been established in Spain.
Isabella succeeded to the throne (1474) on the death of Henry IV.
He was succeeded by Ferdinand, his son by his second marriage, who was already associated with his wife Isabella as joint sovereign of Castile.
In 1281 his first wife died, and on the 5th of February 1284 he married Isabella, daughter of Hugh IV.
He left one son, his successor Alexander II., and two daughters, Margaret and Isabella, who were sent to England after the treaty of 1209, and who both married English nobles, Margaret becoming the wife of Hubert de Burgh.He also left some illegitimate children.