In all cases the dimensions of the leaf are enlarged by interstitial growth of its parts.
According to Wulfert [60] the primitive germ-cells of Gonothyraea can be distinguished soon after the fixation of the planula, appearing amongst the interstitial cells of the ectoderm.
The following day an interstitial emphysema caused by a lung weakness was diagnosed.
Although the significance for man cannot be discounted the NOEL for interstitial cell hyperplasia can be used in the risk assessment.
The other 2, who presented 10 days after consumption of the mushrooms, developed severe interstitial nephritis and did not recover renal function.