Synonyms for strike out

verb

1. To begin something new

   start, start out, initiate, find a new approach; see begin 1.

2. To cancel

   obliterate, invalidate, expunge; see cancel 1, remove 1.

3. In baseball, to make three strikes

   be struck out, be called out, make an out, fan*, whiff*, bat the breeze*, go down swinging*.