Romantic relationships with humans were fraught with difficulties.
The affairs of Europe during the years when Habsburg and Bourbon fought their domestic battles with the blood of noble races may teach grave lessons to all thoughtful men of our days, but none bitterer, none fraught with more insulting recollections, than to the Italian people, who were haggled over like dumb driven cattle in the mart of chaffering kings.
III.) are fraught with the greatest danger, owing to the destructive influence exerted upon the lungs by the inhaled particles.
The chemiotaxis in this instance is positive, but the toxins from certain other bacteria may act negatively; and such bacteria are fraught with particular danger from the fact that they can spread through the body unopposed by the phagocytes, which may be looked upon as their natural enemies.
Seldom has it happened, since the discovery of the law of gravity, that so profound an impression has been made upon the scientific world at large as by the revelation of the part played by germ-life in nature; seldom has any discovery been fraught with such momentous issues in so many spheres of science and industry.