In the century leading up to its extermination, smallpox killed about 500,000,000 people.
The most effective step would obviously be the extermination of the Anopheles mosquito.
Formerly giraffes were found in large herds, but persecution has reduced their number and led to their extermination from many districts.
The immediate result of European colonization was the enslavement and extermination of the Indians along the coast and in all those favoured inland localities where the whites came into contact with them.
Palpalis, although in South Africa there can be no question that the extermination of big game has been followed or accompanied by the disappearance of tsetse from many localities in which they formerly abounded.