Nausea and vomiting are worst in the first trimester when the developing baby is most susceptible to effects from other drugs, consequently, there are limited conventional treatments available.
This therapy is started in the first trimester when fetal adrenal production of androgens begins but before prenatal diagnosis is done that would provide definitive information about the sex of the fetus and its disease status.
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abortion in the third trimester (that is after the point of viability outside the womb ).
In cases of aldosterone-producing adenoma, surgery in the second trimester is the most appropriate option to avoid a poor obstetric outcome.